Frontline Plus for Extra Large Dogs was trusted with veterinarians for tick and flea control for puppies for almost 20 decades. Made with two tough killing ingredients, fipronil, and (S)-methoprene. One to kill mature fleas and ticks and another one to kill flea larvae and eggs. Frontline Plus Flea and Tick Prevention for Extra Large Dogs, 6 Monthly Treatments: Provides fast-acting, long-lasting treatment, and control. Approved for use on dogs 89-132 lbs. Frontline Plus also kills, brown dog tick, the American dog tick, lone star tick, and deer ticks. It also destroys fleas and ticks life cycles by eliminating fleas eggs and fleas larvas.